Cell Line Development

Bionova Scientific™ uses established mammalian expression systems to rapidly develop cell lines to generate Research Cell Banks (RCB). We also generate cell lines to support late stage process development to generate Master Cell Banks (MCB) suitable for cGMP manufacturing use.

GS System

CHOZN® Platform (Sigma)*

Horizon Platform (Horizon)*

BNS CHO Prime Cells™ (CHO-K1)

DHFR System

Freedom® CHO-S® (Thermo)*

BNS CHO Extreme Cells™ (CHO DUXB-11)

BNS CHO Supreme Cells™ (CHO DG44)

* additional license fee from the vendor may be applied at milestone


Bionova Scientific’s cell line engineering team employs the TARGATT™ system to deliver site-specific gene integration for the development of production cell lines. The TARGATT™ system promises to provide unique benefits over existing expression systems.

Our deep experience in cell line development allows us to generate high-performing cell lines with desirable product qualities for the expression of monoclonal antibodies, antibody fragments, bispecific antibodies, Fc fusion proteins, recombinant proteins, antibody-drug conjugates.